Towards a confocal subcellular atlas of the human proteome Towards a confocal subcellular atlas of the human proteome
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Running Title Towards a confocal subcellular atlas of the human proteome Towards a confocal subcellular atlas of the human proteome
منابع مشابه
Toward a confocal subcellular atlas of the human proteome.
Information on protein localization on the subcellular level is important to map and characterize the proteome and to better understand cellular functions of proteins. Here we report on a pilot study of 466 proteins in three human cell lines aimed to allow large scale confocal microscopy analysis using protein-specific antibodies. Approximately 3000 high resolution images were generated, and mo...
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Information on protein localization on the subcellular level is important to map and characterize the proteome and to better understand cellular functions of proteins. Here we report on a pilot study of 466 proteins in three human cell lines aimed to allow large scale confocal microscopy analysis using protein-specific antibodies. Approximately 3000 high resolution images were generated, and mo...
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The systematic study of subcellular location patterns is required to fully characterize the human proteome, as subcellular location provides critical context necessary for understanding a protein's function. The analysis of tens of thousands of expressed proteins for the many cell types and cellular conditions under which they may be found creates a need for automated subcellular pattern analys...
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The Human Genome Project has generated a blueprint for the approximately 20,300 gene-encoded proteins potentially active in any of 230 cell types that make up the human body (human proteome). However, based on the UniProtKB/Swiss-Prot database content, about 6000 of at the protein level; for many others, there is very little information related to protein function, abundance, subcellular locali...
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Consecutive to the human genome project, the human proteome project seeks to explore the function, structure, variability and interaction of proteins which support the daily operation of our human bodies. The identification of protein locations within cells is an essential part. The appearance of the residence of proteins may illustrate the status and functioning of cells, and then organs, tiss...
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